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ToolUniverse Router

Route user questions to specialized skills. If no skill matches, use general strategies from references/general-strategies.md.

Routing Workflow

1. Extract keywords from user's question
2. Scan routing table below for keyword matches
3. Take action :
   • 1 clear match → invoke that skill NOW using the Skill tool
   • Multiple matches → ask user which they prefer (AskUserQuestion)
   • No match → use general strategies (load references/general-strategies.md)
4. If ambiguous (e.g., "Tell me about aspirin") → ask user to clarify intent

CRITICAL : Actually INVOKE skills — don't describe them or show the routing table to the user.

Language : If the user writes in a non-English language, extract keywords for routing but respond in their language. All tool calls use English terms.

Routing Table

1. Data Retrieval

2. Research & Profiling

3. Clinical Decision Support

4. Discovery & Design

5. Genomics & Variant Analysis

6. Systems & Network Analysis

7. Screening & Functional Genomics

8. Clinical Trials & Study Design

9. Outbreak Response

10. Infrastructure & Setup

Tie-Breaking Rules

1. Domain Over Setup : When "how do I", "help me", "explain", or "what is" co-occurs with a domain entity (drug, gene, protein, disease, variant, pathway name), route to the domain skill , NOT setup.

   • "how do I find interactions for TP53?" → protein-interactions
   • "help me research metformin" → drug-research
   • "what is EGFR?" → target-research
   • "I'm new, can you research diabetes?" → disease-research
   • Only route to setup when NO domain entity present ("how do I use this?")

2. Specificity Rule : More specific beats general.

   • "cancer treatment" → precision-oncology (not disease-research)

3. Data Type Rule : "get/retrieve/fetch" → retrieval skills.

   • "get compound structure" → chemical-compound-retrieval (not drug-research)

4. Still ambiguous : Ask user with AskUserQuestion.

When to Use General Strategies

Only when no specialized skill matches:

• Meta-questions about ToolUniverse itself (no domain entity)
• Custom workflows combining multiple skills
• User explicitly says "don't use specialized skills"

WARNING : "how do I find interactions for TP53?" is NOT a meta-question — route to protein-interactions.

When using general strategies, load references/general-strategies.md and execute them (run actual queries, don't just describe).

Routing Examples

Clear match : "comprehensive research report on breast cancer" → Skill(skill="tooluniverse-disease-research", args="breast cancer")

Ambiguous : "Tell me about aspirin" → AskUserQuestion: drug profile, safety, chemical data, or repurposing?

No match : "How can I find all tools related to proteomics?" → General strategies: run find_tools queries

Domain + setup keyword : "help me understand BRCA1 variants" → Skill(skill="tooluniverse-variant-interpretation", args="BRCA1")

Weekly Installs

175

Repository

mims-harvard/to…universe

GitHub Stars

1.2K

First Seen

Feb 4, 2026

Security Audits

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Installed on

codex167

opencode165

gemini-cli162

github-copilot159

amp154

kimi-cli153